TABLE 1.

Cosinor analysis of physiological parameters following cigarette smoke exposure.

	Mesor	Amplitude	Acrophase, hours	R2
Temperature, C
Baseline	36.7 ± 0.0	0.7 ± 0.0	8.6 ± 0.1	0.93
Week 1	36.8 ± 0.0*	0.5 ± 0.1*	9.0 ± 0.1*	0.81
Week 4	36.6 ± 0.0	0.5 ± 0.0*	9.1 ± 0.1*	0.86
Week 8	36.7 ± 0.0	0.6 ± 0.1	15.3 ± 0.1*	0.82
Week 24	37.1 ± 0.0*	0.8 ± 0.1	15.2 ± 0.1*	0.89
HR, bpm
Baseline	582 ± 3	59 ± 4	14.6 ± 0.1	0.89
Week 1	623 ± 4*	44 ± 6*	15.0 ± 0.1*	0.75
Week 4	555 ± 5*	79 ± 7*	9.0 ± 0.1*	0.85
Week 8	564 ± 5*	78 ± 7*	9.1 ± 0.1*	0.84
Week 24	501 ± 3*	45 ± 4*	9.0 ± 0.1*	0.88
SBP, mmHg
Baseline	103.2 ± 0.8	17.0 ± 1.1	2.3 ± 0.1	0.92
Week 1	119.6 ± 1.3*	6.7 ± 1.8*	9.3 ± 0.3*	0.39
Week 4	147.1 ± 1.6*	23.1 ± 2.3*	9.3 ± 0.1*	0.83
Week 8	119.8 ± 2.1*	21.9 ± 2.9	9.4 ± 0.1*	0.73
Activity, AU
Baseline	3.9 ± 0.2	3.2 ± 0.3	14.6 ± 0.1	0.86
Week 1	3.4 ± 0.2*	1.8 ± 0.3*	15.0 ± 0.2*	0.63
Week 4	5.0 ± 0.3*	4.6 ± 0.5*	15.1 ± 0.1*	0.81
Week 8	4.9 ± 0.4*	4.5 ± 0.5*	15.2 ± 0.1*	0.77
Week 24	5.6 ± 0.4*	4.6 ± 0.5*	21.3 ± 0.1*	0.78

Data are mean ± SEM. SBP, systolic blood pressure; HR, heart rate; mesor, midline estimating statistic of rhythm; amplitude, half the extent of predictable variation within a cycle; acrophase, the time of overall high values recurring in each cycle; R², degree of curve fit. * indicates significance (P < 0.05).