Fig. 2.

Metabolic network analyses using significantly changed metabolites in BALF and serum. (A) Enriched metabolic networks in BALF and serum. The green line indicates the threshold (P = 0.05). The number above each bar indicates the number of mapped metabolites in the network. (B) (l)‐Proline pathways and transport in metacore version 19.4. The green, red, and gray arrows indicate positive effect, negative effect, and unspecified effect, respectively. Closed red circles or mixed red/blue circles indicate differentially changed metabolites in BALF or serum samples from fibrotic lung mice, while red squares indicate proline‐ or methionine‐related genes. Further explanations are provided at https://portal.genego.com/legends/MetaCoreQuickReferenceGuide.pdf.