Table 2.

TXNIP expression in cancers of the digestive system.

Tumor type	Upstream or downstream molecular	Significance	TXNIP expression	Samples	References
Liver cancer	Vitamin D3	VitaminD3 can increase the expression of TXNIP to inhibit the proliferation of liver cancer cells	Down	Cell lines	(69)
Liver cancer	ChREBP	ChREBP binds to the upstream promoter region of TXNIP and promote TXNIP's expression	Down	Cell lines, tissue, animal	(70)
Liver cancer	HBx	X protein promotes the expression of TXNIP	Down	Cell lines, tissue	(71)
Liver cancer	ROS	overexpression of TXNIP inhibits the proliferation of hepatoma cells by producing of ROS	Down	Cell lines, tissue	(72)
Pancreatic cancer	miR-224/HIF1	miR-224 targets the 3'UTR of TXNIP to promote the proliferation and migration of PDAC	Down	Cell lines, tissue	(73)
Pancreatic cancer	Fbw 7	FBW7 can inhibit the expression of c-myc in PDAC to inhibit the occurrence and development of tumor	Down	Cell lines, tissue, animal	(74)
Gastric cancer	TNF-α, NF-κB and COX-2	Disrupting cell growth	Down	Cell lines, tissue	(75)

ChREBP, the carbohydrate response element binding protein; ROS, Reactive oxygen species; HIF1, hypoxia-inducible factor; Fbw 7, F-box and WD repeat domain-containing7; TNF-α, TumorNecrosisFactor-α; NF-κB, nuclear factor kappa-B; COX-2, Cyclooxygenase-2.