FIGURE 2.

Proteins involved in the interplay between the plasma membrane components and the cytoskeleton in T cells. Structural organization of proteins regulating the interplay between membrane components and the actin and microtubule cytoskeletons. The modular domains involved in their interactions with lipids or other proteins are highlighted. Each domain, named on top, is shown in a different color and its interacting molecules depicted below in italics. ERMs and talin are mostly involved in the localization of adhesion proteins to particular areas of the plasma membrane, as the uropod (ERMs), or the immunological synapse periphery (talin). Dlg1, Apc, Scrib, Lgl, and PKCζ are polarity regulators involved in T cell migration and/or immunological synapse formation. For ERM, the phosphorylatable regulatory threonine residue (pThr) in the C-terminal domain is also shown. Molecular weights in kDa are show below each protein name.