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Schematic presentation of SLC6A14 trafficking from endoplasmic reticulum (ER) to plasma membrane. Sequential binding of HSP70, HSP90 and Sec24C in a SEC24/SEC23 dimer is shown in the left bottom part. Inhibition of HSP90 leads to SLC6A14 proteosomal degradation (right, middle part). Coatomer II (COPII) vesicle is shown as a magnified image when vesicles are trafficking between ER and cis-Golgi. Details are described in the text.
