. 2020 Oct 21;8:594464. doi: 10.3389/fcell.2020.594464

TABLE 1.

Transporters from SLC6 family.

Transporter	Main substrate(s)	Cotransported ions	References
*GABA, osmolyte, creatine transporters*:
SLC6A1/GAT1	GABA	2Na⁺, 1C1-	Nelson et al., 1990; Pantanowitz et al., 1993
SLC6A6/TauT	taurine, p-alanine	2Na⁺, 1C1-	Liu et al., 1992a; Ramamoorthy et al., 1994
SLC6A8/CTl/CreaTl	creatine	2Na⁺, 1C1-	Dai et al., 1999; Nash et al., 1994
SLC6A10/CT2/CreaT2	creatine	2Na⁺, 1C1-*	Iyer et al., 1996; Xu et al., 1997
SLC6A11/GAT3	GABA	2Na⁺, 1C1-	Borden et al., 1994; Clark and Amara, 1994; Karakossian et al., 2005; Liu et al., 1993b
SLC6A12/BGT1	betaine/GABA	3Na⁺, 1C1-	Lopez-Corcuera et al., 1992; Yamauchi et al., 1992
SLC6A13/GAT2	GABA	2Na⁺, 1C1-	Borden et al., 1994; Liu et al., 1993b
*Monoamine neurotransmitter transporters*:
SLC6A2/NET	norepinephrine,
	dopamine	lNa⁺, 1C1-	Gu et al., 1994; Gu et al., 1996; Pacholczyk et al., 1991
SLC6A3/DAT	dopamine	2Na⁺, 1C1-	Gu et al., 1994; Shimada et al., 1991
SLC6A4/SERT	serotonin	1Na⁺, 1Cl^–, 1K⁺	Gu et al., 1994; Hoffman et al., 1991
*Amino acid transporters (I):*
SLC6A5/GlyT2	glycine	3Na⁺, 1C1-	Liu et al., 1993a; Roux and Supplisson, 2000
SLC6A7/PROT	proline	2Na⁺, 1C1-	Fremeau et al., 1992; Galli et al., 1999
SLC6A9/GlyTl	glycine	2Na⁺, 1C1-	Liu et al., 1992b; Roux and Supplisson, 2000
SLC6A14/ATB^{0, +}	neutral,
	cationic amino acids	2Na⁺, 1C1-	Nakanishi et al., 2001; Sloan and Mager, 1999
*Amino acid/nutrient transporters (II):*
SLC6A15/B°AT2	large, neutral
	amino acids	lNa⁺	Broer et al., 2006
SLC6A16/NTT5	unknown orphan
SLC6A17/NTT4	neutral amino acids	lNa⁺	Parra et al., 2008; Zaia and Reimer, 2009
SLC6A18/B°AT3	neutral amino acids	2Na⁺, 1C1-
SLC6A19/B°AT1	neutral amino acids	lNa⁺	Broer et al., 2004
SLC6A20/SIT1/
system IMINO	proline, pipecolate,
	sarcosine	2Na⁺, 1 Cl^–	Kowalczuk et al., 2005; Takanaga et al., 2005

GABA, γ-aminobutyric acid; ^∗, stoichiometry not determined.