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. 2020 Oct 21;8:556543. doi: 10.3389/fcell.2020.556543

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Copyright © 2020 Lang, Rajaxavier, Singh, Brucker and Salker.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SGK1 and pregnancy loss: Expression of SGK1 rises in the decidual (stroma) compartment of the endometrium to sustain early pregnancy. SGK1 modulates cell differentiation, proliferation and survival of the decidua and provide with antioxidant defenses at the feto-maternal interface. Thus, when SGK1 levels fall in the decidual stroma it results in poor cell proliferation, reduction in antioxidant defense resulting in cell death and reduction in histotrophic nutritional support causing early pregnancy loss. Low maternal SGK1 levels could also possibly influence endometrial angiogenesis and fetal programming.