. 2020 Oct 21;8:556543. doi: 10.3389/fcell.2020.556543

TABLE 3.

SGK1-regulated target proteins.

Target	Example	References
Stimulation of enzymes	ubiquitin ligase NEDD4-2, inducible nitric oxide synthase (iNOS), phosphomannose mutase 2 (PMM2), phosphatidylinositol-3-phosphate-5-kinase (PIKfyve), serine/threonine kinase WNK4, ERK2, mitogen-activated protein kinase/ERK kinase kinase 3 (MEKK3), stress-activated kinase (SEK1), B-Raf kinase, glycogen synthase kinase 3 (GSK-3), p53-ubiquitinating MDM2 Notch1-IC protein degrading Fbw7	Firestone et al., 2003; Lang and Stournaras, 2013
Stimulation of transcription factors	CREB, AP-1, p53 tumor suppressor protein, CBFA1, MSX2, SOX9	Terada et al., 2008; Rotte et al., 2011; Borst et al., 2012; Eylenstein et al., 2012; Lang and Stournaras, 2013; Firestone et al., 2003; Lang et al., 2006, 2018.
Inhibition of transcription factors	NFκB, p53, forkhead box O3a- protein (FOXO3a)	Murakami et al., 2010; Lang and Stournaras, 2013. Dehner et al., 2008; Lang and Stournaras, 2013; Sahin et al., 2013.
Ion channels	epithelial sodium channel (ENaC), voltage-gated Na⁺ channels (SCN5A), acid sensing (ASIC1) Na⁺ channels, renal outer medullary K⁺ channels (ROMK1) voltage-gated K⁺ channels KCNE1/KCNQ1, KCNQ4, voltage-gated K⁺ channels Kv1.3, Kv1.5, Kv7.2/3, Kv4.3, voltage-gated K⁺ channels hERG, Ca²⁺release-activated Ca²⁺ channel ORAI and its stimulator STIM, transient receptor potential channels (TRPV4, TRPV5, TRPV6), kainate receptor GluR6, unselective cation channel 4F2/LAT, ClCka/barttin Cl^– channels, ClC2 Cl^– channels, CFTR Cl^– channels, VSOAC Cl^– channels	Giebisch, 1998; Arteaga and Canessa, 2005; Seebohm et al., 2005; Lang et al., 2006; Lang and Shumilina, 2013.
Carriers and pumps	Na⁺,K⁺,2Cl^– cotransporters (NKCC2), NaCl cotransporter (NCC), Na⁺/H⁺ exchangers (NHE1, NHE3), facilitative (GLUT1, GLUT4), Na⁺-coupled (SGLT1) glucose transporters, amino acid (ASCT2, SN1, B(0)AT1, EAAT1, EAAT2, EAAT3, EAAT4, EAAT5) peptide (PepT) transporters, Na⁺,dicarboxylate cotransporter (NaDC-1), creatine transporter (CreaT), Na⁺,myoinositol cotransporter (SMIT), phosphate carriers (NaPiIIa, NaPiIIb), Na⁺/K⁺-ATPase, albumin uptake	Lang et al., 2006, 2014. Lang et al., 2006; Lang and Stournaras, 2013.
Signaling molecules etc.,	nephrin, type A natriuretic peptide receptor (NPR-A), Ca²⁺-regulated heat-stable protein of apparent molecular mass 24 kDa (CRHSP24), adaptor precursor (APP) Fe65, NDRG1 and NDRG2, myosin-Vc, filamin C, microtubule-associated protein tau, Cyclin-dependent kinase inhibitor 1B (p27^Kip1), huntingtin	McCaig et al., 2011; Ohashi et al., 2011; Lang and Stournaras, 2013; Sahin et al., 2013; Voelkl et al., 2015; Lang et al., 2018.