Figure 7.

FOXL2^OE mice were infertile with abolished decidual responses. All the Pgr^cre mice but none of the FOXL2^OE mice delivered any pups during 6-month breeding trial (A). Representative pictures of estrous cycle showed continuous diestrus in FOXL2^OE mice (C) in contrast to the estrous cycle showed in Pgr^cre mice (B) during 14-day period. Representative ovarian histology pictures of Pgr^cre (D–F) and FOXL2^OE (G–I) virgin mice at diestrus stage at the age of PND21 (D and G), 3 M (E and H), and 8 M (F and I). FOXL2^OE ovaries were depleted of corpus luteum. The representative pictures of the hormone primed uterus after 5-day oil injections in the Pgr^cre (J) and FOXL2^OE (K) mice. The weight ratio of the oil-injected side over the un-injected side uterine horn (L) confirmed that the decidualization occurred in all the Pgr^cre but none of the FOXL2^OE mice. Arrow indicates the oil-injected side. D: diestrus; P: proestrus; Me: metestrus; E: estrus; PND: postnatal day; M: months old; CL: corpus luteum. The arrow indicates oil injected uterine horn. N = 6 for each genotype and age group.