Table 2.
Characteristics of study cohort, stratified by procurement biopsy technique
| Characteristic | All (n = 392) | Wedge biopsy (n = 171, 44%) | Core biopsy (n = 221, 56%) | P |
|---|---|---|---|---|
| Donor characteristic | ||||
| Age, yr | 44 (12) | 46 (11) | 42 (13) | <0.001 |
| Female sex | 161 (41) | 73 (43) | 88 (40) | 0.57 |
| Hypertension | 153 (39) | 81 (47) | 72 (33) | 0.003 |
| Diabetes mellitus | 53 (14) | 24 (14) | 29 (13) | 0.79 |
| Obesity | 264 (67) | 127 (74) | 137 (62) | 0.01 |
| Final creatinine (mg/dl) | 2.10 ± 1.87 | 2.29 ± 1.72 | 1.95 ± 1.96 | 0.07 |
| Kidney donor risk index | 1.15 ± 0.30 | 1.21 ± 0.26 | 1.11 ± 0.33 | 0.002 |
| Procurement biopsy characteristic | ||||
| Renal pathologist | 36 (9) | 30 (18) | 6 (3) | <0.001 |
| Performed at our center’s local organ procurement organization | 188 (48) | 1 (1) | 187 (85) | <0.001 |
| Number of glomeruli | 49 ± 30 | 56 ± 35 | 44 ± 25 | <0.001 |
| Advanced glomerulosclerosis | 88 (22) | 54 (32) | 34 (15) | <0.001 |
| Advanced interstitial fibrosis/tubular atrophy (n = 380)a | 6/380 (2) | 6/165 (4) | 0/215 (0) | 0.005 |
| Advanced vascular disease (n = 373)a | 69/373 (18) | 19/159 (12) | 50/214 (23) | 0.005 |
| Compartment concordance | 189 (48) | 63 (37) | 126 (57) | <0.001 |
| Bilateral concordance | 283 (72) | 139 (81) | 144 (65) | <0.001 |
| Comparison to reperfusion biopsy | ||||
| Discordant overall histologic classification | 134 (34) | 62 (36) | 72 (33) | 0.45 |
| Reperfusion histology more favorable | 57 (15) | 18 (11) | 39 (18) | 0.05 |
| Number of discordant compartments | 0.03 | |||
| 0 | 219 (56) | 85 (50) | 134 (61) | |
| 1 | 139 (35) | 64 (37) | 75 (34) | |
| 2 | 33 (8) | 21 (12) | 12 (5) | |
| 3 | 1 (0.3) | 1 (0.6) | 0 (0) | |
| Discordant glomerulosclerosis | 103 (26) | 51 (30) | 52 (24) | 0.16 |
| Discordant interstitial fibrosis/tubular atrophy (n = 380)a | 6 (2) | 6/165 (4) | 0/215 (0) | 0.006 |
| Discordant vascular disease (n = 373)a | 99 (27) | 52/159 (33) | 47/214 (22) | 0.02 |
Data are n (%) or mean ± SD.
a
A total of 12 biopsies were missing information about interstitial fibrosis/tubular atrophy, and 19 were missing information about vascular disease. These biopsies were excluded from the relevant rows.