Table 3.
Association results for SNVs in inflammasome-encoding genes in the TB cohort from the Brazilian State of Amazonas.
| Gene SNV ID | Effect | Genotypes | HD (n = 288) | TB (n = 352) | padj ORadj (95%CI) | PTB (n = 288) | ETB (n = 64) | padj ORadj (95%CI) |
|---|---|---|---|---|---|---|---|---|
| NLRP3rs10754558 | GoF | C/C | 0.52 | 0.65 |
0.003
0.16 (1.02–1.29) |
0.68 | 0.62 | 0.475 0.96 (0.64–3.56) |
| C/G | 0.35 | 0.31 | 0.27 | 0.34 | ||||
| G/G | 0.13 | 0.04 | 0.05 | 0.04 | ||||
| NLRC4rs479333 | LoF | G/G | 0.66 | 0.49 | 0.658 0.78 (0.25–2.43) |
0.39 | 0.60 |
0.0006
0.20 (1.92–13.16) |
| C/G | 0.20 | 0.31 | 0.39 | 0.23 | ||||
| C/C | 0.14 | 0.20 | 0.22 | 0.17 |
Gene symbol, variant identification number (SNV ID), genotypes frequencies for patients with active pulmonary TB (PTB) extra-pulmonary (ETB) and healthy donors (HD), GLM p-value (p), odds ratio (OR) and 95% confidence interval (CI) are reported adjusted for sex and age (padj, ORadj). Statistically significant results after Bonferroni correction are indicated in bold characters.