Table 5.
Discriminatory ability of cardiac biomarker to predict all-cause and CV mortality in the CRIC study
| Cardiac biomarker | Model 0 |
Model 1 |
|
|---|---|---|---|
| 10-Fold CV C-index (95% bootstrap CI) | 10-Fold CV C-index (95% bootstrap CI) | Difference in C-index, compared to model 0 (95% bootstrap CI) | |
| Overall mortality | |||
| NT-proBNP | 0.74 (0.72, 0.76) | 0.77 (0.75, 0.78) | 0.03 (0.02, 0.04) |
| hsTNT | 0.74 (0.72, 0.76) | 0.76 (0.74, 0.78) | 0.02 (0.01, 0.03) |
| GDF-15 | 0.74 (0.72, 0.76) | 0.76 (0.74, 0.77) | 0.02 (0.01, 0.02) |
| Galectin-3 | 0.74 (0.72, 0.76) | 0.75 (0.73, 0.76) | 0.00 (0.00, 0.01) |
| sST-2 | 0.74 (0.72, 0.76) | 0.75 (0.73, 0.76) | 0.01 (0.00, 0.01) |
| CV mortality | |||
| NT-proBNP | 0.77 (0.75, 0.80) | 0.80 (0.78, 0.82) | 0.03 (0.02, 0.04) |
| hsTNT | 0.77 (0.75, 0.80) | 0.79 (0.77, 0.81) | 0.02 (0.01, 0.03) |
| GDF-15 | 0.77 (0.75, 0.80) | 0.79 (0.76, 0.81) | 0.01 (0.00, 0.02) |
| Galectin-3 | 0.77 (0.75, 0.80) | 0.77 (0.75, 0.80) | 0.00 (0.00, 0.01) |
| sST-2 | 0.77 (0.75, 0.80) | 0.78 (0.75, 0.80) | 0.01 (0.00, 0.01) |
CRIC, Chronic Renal Insufficiency Cohort; CV, cardiovascular; GDF-15, growth differentiation factor−15; hsTnT, high-sensitivity troponin T; NT-proBNP, N-terminal pro-B-type natriuretic peptide; sST-2, soluble ST-2.
Model 0: age, sex, race/ethnicity, site, diabetes, cardiovascular disease, body mass index, smoking, systolic blood pressure, low-density lipoprotein, high-density lipoprotein, estimated glomerular filtration rate, log-transformed 24-hour urinary protein. Model 1: M0 + log-transformed biomarker.