Table 7.

Candidates for salivary biomarkers in oral cancer: based on biomolecules

Genomic markers	Salivary transcriptome markers (mRNA)	Salivary protein markers	Other markers
-Mutation p53 genes codon 63 -Promoter hypermethylation of: +DAPK gene +TIMP3 gene +p16 gene +MGMT gene -Cyclin D1 gene amplification -Decrease in mammary serine protease inhibitor (Maspin)	-IL-8 -IL-1 -S100P -SAT (spermidine/spermine N1-acetyltransferase) -miR 125, miR 31, miR 200a	-Elevated CD44 -IL-6 -Intermediate filament protein (Cyfra 21-1) -8-OHdG DNA damage marker (8-OHdG) -Albumin -Glutathione -Actin and myosin -L-phenylalanine -EFNB2, ANGPT1, ANGPT2, CD31, VEGF	-Presence of HPV and EBV -Salivary non-organic compound: Na, Ca, F, Mg -Fucose