Fig. 1.

Forest plot and meta-analysis of HRs for pancreatic cancer, comparing regular statin users with non-regular users in the NHS and HPFS cohorts. Squares and horizontal lines indicate cohort-specific multivariable-adjusted HRs and 95% CIs, respectively. Area of the square reflects cohort-specific weight (inverse of the variance). Diamond indicates pooled multivariable-adjusted HR (center) and 95% CI (width). HRs were adjusted for age (continuous), sex (cohort), race/ethnicity (white, black, other, or unknown), calendar year of questionnaire cycle (continuous), smoking in pack-years (never, 0.1-4.9, 5-19.9, 20-39.9, or ≥ 40), history of diabetes (yes/no), body mass index (< 25, 25-29.9, 30-34.9, or ≥ 35 kg/m²), physical activity (MET-hours per week in quintiles), alcohol intake (0, 0.1-4.9, 5-14.9, 15-29.9, or ≥ 30 g/day), and regular multivitamin use (yes/no).

CI, confidence interval; HPFS, Health Professionals Follow-up Study; HR, hazard ratio; MET, metabolic equivalent of task; NHS, Nurses’ Health Study.