. Author manuscript; available in PMC: 2020 Nov 4.

Published in final edited form as: J Gastroenterol. 2018 Jan 23;53(8):959–966. doi: 10.1007/s00535-018-1430-x

Table 4.

Risk of incident pancreatic cancer by duration of regular statin use in the combined population

	Duration of regular statin use (years)				P_trend^c
	Non-regular use	> 0-2	3-5	≥ 6	P_trend^c
No. of cases	355	73	46	108
Person-years	874,688	153,181	104,602	234,328
Age-adjusted HR (95% CI)	1 (referent)	1.14 (0.89-1.47)	1.01 (0.74-1.37)	1.05 (0.84-1.31)	0.66
Multivariable HR (95% CI)^a	1 (referent)	1.04 (0.81-1.35)	0.93 (0.68-1.27)	0.96 (0.77-1.20)	0.65
Multivariable HR (95% CI)^b	1 (referent)	1.04 (0.81-1.35)	0.93 (0.68-1.27)	0.96 (0.77-1.20)	0.65

The Cox proportional hazards regression models were adjusted for age (continuous), sex (cohort), calendar year of questionnaire cycle (continuous), smoking in pack-years (never, 0.1-4.9, 5-19.9, 20-39.9, or ≥ 40), and history of diabetes (yes/no).

Further adjusted for race/ethnicity (white, black, other, or unknown), body mass index (< 25, 25-29.9, 30-34.9, or ≥ 35 kg/m²), physical activity (MET-hours per week in quintiles), alcohol intake (0, 0.1-4.9, 5-14.9, 15-29.9, or ≥ 30 g/day), and regular multivitamin use (yes/no).

P_trend was calculated using a linear tend test and ordinal categories of duration of regular statin use.

CI, confidence interval; HR, hazard ratio; MET, metabolic equivalent of task.