Table 1. Utility of BAT for culprit drug identification in immediate DHR.

Drugs		Markers	Cutoff	Sensitivity (%)	Specificity (%)	Reference
Beta-lactams
	AMX, AMP, PEN, CEFU	CD63	≥5%, SI≥2	49–55	91–100	[19,20]
	AMX, AMP, CEF-3, CEFT, CEFU	CD63, CD203c	≥5%, SI≥2	33	100	*
Quinolones
	MOX, LEV, CIP, OLF	CD63, CD203c	≥5%, SI≥2	71	100	[21,22]
NMBAs
	PAN, ROC, ATA, SUX	CD63, CD203c	>4%, >10%	80–100	96–100	[23,24]
RCM
	IOB, IOX, IOP, IOH, IOPA, IOM	CD63	≥5%, SI≥2	46–63	89–100	[25,26]
	IOB, IOH, IOP, IOX	CD63, CD203c	≥5%, SI≥2	25	ND	*
NSAIDs
	ASA, DIC, KET, CEL, ACT	CD63	≥5%, SI≥ (1.71–2.18)	37–61	90–91	[27,28,29]
	DIC, IBU, ACT	CD63, CD203c	≥5%, SI≥2	33	100	*

BAT, basophil activation tests; DHR, drug hypersensitivity reactions NMBAs, neuromuscular blocking agents; RCM, radiocontrast media; NSAIDs, nonsteroidal anti-inflammatory drugs containing ibuprofen, diclofenac, tramadol; ND, not determined; AMX, amoxicillin; AMP, ampicillin; PEN, penicillin; CEFU, cefuroxime; CEF-3, ceftriaxone; CEFT, ceftazidime; MOX, moxifloxacin; LEV, levofloxacin; CIP, ciprofloxacin; OLF, ofloxacin; PAN, pancuronium; ROC, rocuronium; ATA, atacurium; SUX, sumamethonium; IOB, iobitridol; IOH, iohexol; IOM, iomeprol; IOP, iopromide; IOPA, iopamidol; IOX, ioxithalamate; ASA, aspirin; DIC, diclofenac; KET, ketoprofen; CEL, celecoxib; ACT, acetaminophen; SI, stimulation index.

^*Data of our studies, unpublished data.