Table 4. Factors affecting results of BAT and LTT.
| Outcomes | BAT | LTT |
|---|---|---|
| False-negative results may be obtained if [31,32,45] | Performed within 1–2 weeks after recently reaction (refractory period) | - |
| Systemic corticosteroid, immunosuppressant drugs (cyclosporin A) | Systemic corticosteroid, immunosuppressant drugs, chemotherapeutic drugs | |
| Last reaction > 1 yr | Last reaction > 2–3 yr | |
| Prolonged blood handling > 24 hr | Prolonged blood handling > 24 hr | |
| Nonresponder to controls | Nonresponder to controls | |
| - | High/toxic doses lead to cell death | |
| False-positive results may be obtained if [32,45] | - | AGEP, SJS/TEN: within 1 month after recovery |
| DRESS: within 3 months after recovery | ||
| - | Some drugs (vancomycin, acetaminophen, RCM, NSAIDs) | |
| High/irritating doses leading to nonspecific degranulation | - |
BAT, basophil activation test; LTT, lymphocyte transformation test; AGEP, acute generalised exanthematous pustulosis; DRESS, drug reaction with eosinophilia and systemic symptoms; SJS/TEN, Stevens-Johnson syndrome/toxic epidermal necrolysis; RCM, radiocontrast media; NSAIDs, nonsteroidal anti-inflammatory drugs.