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. 2020 Oct 5;10(4):e35. doi: 10.5415/apallergy.2020.10.e35

Table 1. Patient response to the oral fish collagen challenge test.

Time after OFC (min) Dose of fish collagen* (g) Vital sign Symptoms and signs Treatment
SpO2 (%) BP (mmHg)
Before OFC 98 97/61 No symptoms
0 0.3
1 100 103/57 Discomfort in the pharynx and larynx Oral antihistamines
15 100 97/64 Pharyngeal obstruction and moderate abdominal pain Nebulized adrenaline
50 100 106/84 Cold distal limbs Infusion of normal saline and prednisolone
115 100 103/57 Redness and a wheal around the face
180 98 94/51 All symptoms and signs resolved

OFC, oral food challenge test; SpO2, percutaneous oxygen saturation; BP, blood pressure.

*A sample of the fish collagen used in the gummy tablets was provided by the manufacturer; 1 g was added to 3 mL of water and melted in a 500-W microwave for 30 seconds. The patient consumed 1 g of the product, equivalent to 0.3 g of fish collagen.