Figure 1.

Relationship between circulating insulin levels and body glucose disposal in the absence or presence of sodium–glucose cotransporter 2 (SGLT2) inhibitor. Individuals with insulin resistance require larger amounts of insulin to maintain a certain level of glucose disposal. Administration of SGLT2 inhibitor to such individuals reduces the level of glucose disposal necessary to maintain glycemia as a result of the induced increase in urinary glucose excretion. The amount of insulin required for a certain level of glucose disposal, on which the evaluation of insulin resistance is usually based, might thus decrease, even without amelioration of insulin resistance. f‐IRI, fasting immunoreactive insulin; FPG, fasting plasma glucose; HOMA‐IR, homeostasis model assessment–insulin resistance; U‐glucose, urinary glucose.