Table 1.
Baseline characteristics of two study populations (patients aged 25-84 years without history of cardiovascular disease (CVD) or previous statin use). Values are numbers (percentages) unless stated otherwise
| Characteristics | Overall cohort | Cohort without censoring | |||
|---|---|---|---|---|---|
| Derivation cohort (n=2 746 453) | Validation cohort (n=915 479) | Derivation cohort (n=335 632) | Validation cohort (n=111 868) | ||
| CVD cases | 86 769 (3.2) | 28 828 (3.1) | 78 826 (23.5) | 26 168 (23.4) | |
| Patients censored within 10 years | 2 410 516 (87.8) | 803 916 (87.8) | NA | NA | |
| CVD risk factors | |||||
| Female sex | 1 406 796 (51.2) | 469 098 (51.2) | 173 691 (51.8) | 58 169 (52.0) | |
| Mean (SD) age, years | 44.7 (15.6) | 44.7 (15.7) | 53.3 (16.2) | 53.4 (16.2) | |
| Mean (SD) body mass index | 26.7 (5.0) | 26.7 (5.0) | 27.2 (4.8) | 27.1 (4.8) | |
| Mean (SD) total cholesterol/high density lipoprotein cholesterol ratio | 3.9 (1.3) | 3.9 (1.3) | 4.1 (1.3) | 4.1 (1.3) | |
| Atypical antipsychotic drug | 12 306 (0.4) | 4030 (0.4) | 932 (0.3) | 316 (0.3) | |
| Antihypertensive treatment | 183 964 (6.7) | 61 962 (6.8) | 42 704 (12.7) | 14 245 (12.7) | |
| Regular steroid tablets | 2059 (0.1) | 694 (0.1) | 289 (0.1) | 100 (0.1) | |
| History of systemic lupus erythematosus | 1840 (0.1) | 606 (0.1) | 257 (0.1) | 74 (0.1) | |
| History of angina or heart attack in first degree relative <60 years | 98 455 (3.6) | 32 619 (3.6) | 7950 (2.4) | 2669 (2.4) | |
| History of atrial fibrillation | 20 778 (0.8) | 6965 (0.8) | 5213 (1.6) | 1757 (1.6) | |
| History of chronic kidney disease (stage 3, 4, or 5) | 30 133 (1.1) | 10 240 (1.1) | 4364 (1.3) | 1514 (1.4) | |
| History of erectile dysfunction | 39 651 (1.4) | 13 110 (1.4) | 3867 (1.2) | 1287 (1.2) | |
| History of migraines | 177 439 (6.5) | 59 106 (6.5) | 19 629 (5.8) | 6593 (5.9) | |
| History of rheumatoid arthritis | 16 167 (0.6) | 5459 (0.6) | 3043 (0.9) | 1030 (0.9) | |
| History of severe mental illness | 219 861 (8.0) | 72 832 (8.0) | 32 190 (9.6) | 10 673 (9.5) | |
| History of type 1 diabetes | 5899 (0.2) | 2097 (0.2) | 820 (0.2) | 251 (0.2) | |
| History of type 2 diabetes | 35 569 (1.3) | 11 826 (1.3) | 8134 (2.4) | 2641 (2.4) | |
| Mean (SD) systolic blood pressure | 126.9 (16.7) | 126.9 (16.7) | 133.1 (18.4) | 133.1 (18.4) | |
| Mean (SD) standard deviation of each individual patient’s systolic blood pressure | 9.9 (5.6) | 9.9 (5.6) | 10.7 (5.9) | 10.7 (5.9) | |
| Ethnicity | |||||
| Other ethnicity | 173 271 (6.3) | 58 124 (6.3) | 6900 (2.1) | 2273 (2.0) | |
| White or not recorded | 2 573 182 (93.7) | 857 355 (93.7) | 328 732 (97.9) | 109 595 (98.0) | |
| Smoking | |||||
| Ex-smoker | 629 500 (22.9) | 209 186 (22.8) | 76 060 (22.7) | 25 429 (22.7) | |
| Current smoker | 806 978 (29.4) | 269 717 (29.5) | 94 082 (28.0) | 31 335 (28.0) | |
| Never smoker | 1 309 975 (47.7) | 436 576 (47.7) | 165 490 (49.3) | 55 104 (49.3) | |
| Townsend deprivation | |||||
| Score 1—Least deprived | 600 392 (21.9) | 199 937 (21.8) | 86 596 (25.8) | 29 156 (26.1) | |
| Score 2 | 594 739 (21.7) | 197 677 (21.6) | 82 211 (24.5) | 27 266 (24.4) | |
| Score 3 | 572 903 (20.9) | 191 045 (20.9) | 69 897 (20.8) | 23 326 (20.9) | |
| Score 4 | 568 006 (20.7) | 189 520 (20.7) | 60 424 (18.0) | 20 140 (18.0) | |
| Score 5—Most deprived | 410 413 (14.9) | 137 300 (15.0) | 36 504 (10.9) | 11 980 (10.7) | |