Table 2.

Full factorial 2¹ × 3¹ design employed for optimizing fluconazole loaded Eudragit RS100 and Eudragit RL100 nanoparticles.

		Level
	Low	Medium	High
	−1	0	+1
X1(A) type of Eudragit	Eudragit RS		Eudragit RL
X2 (B) amount (mg)	100	200	300
Dug to polymer ratio	(1:4)	(1:8)	(1:12)
Response dependent variable		Constrains
Y1 particle size		Minimize
Y2 zeta potential		Maximize
Y3 entrapment efficiency		Maximize