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Unbound brain-to-plasma concentration ratios at steady state (Kp,uu,brain) and observed concentration–time profiles for the unbound drug concentration in brain interstitial fluid (open triangles) and plasma (open circles), and total drug concentration in plasma (filled circles) after intravenous administration of free methotrexate, free methotrexate + empty liposomes, and different liposomal formulations10 (with permission from the publisher).
