Table I.

Diverse molecular functions of aspartate β-hydroxylase in cancer.

First author, year	Cancer type	Mechanisms	Molecular targets	(Refs.)
Cantarini et al, 2006; Chung et al, 2016	Hepatocellular carcinoma	Activating Notch signaling pathway	Notch receptors and ligands	(30,31)
Iwagami et al, 2016		Delaying cell senescence	Inhibition of GSK3β phosphorylation	(47)
Tang et al, 2017		Destroying mitochondria integrity	Decrease of the interaction between histone H2A member X and mitochondrial transcription factor A	(60)
Yoo et al, 2009	Cholangiocarcinoma	Enhancing sarcomatous change and epithelial-mesenchymal transition	Unknown	(67)
Huang et al, 2016; Sugimachi et al, 2001		Activating Notch signaling pathway	Notch receptors and ligands	(68,69)
Huang et al, 2018		Delaying cell growth and senescence	Enhancement of RB1 phosphorylation	(71)
Jove and Hanafusa, 1987	Pancreatic carcinoma	Activating SRC signaling pathway	Interaction with ADAM12/ADAM15	(77)
Dong et al, 2015		Activating Notch signaling pathway	Notch receptors and ligands	(29)
Benelli et al, 2020	Colorectal carcinoma	Activating Notch signaling pathway	Notch receptors and ligands	(81)
Lin et al, 2019	Breast carcinoma	Activating Notch signaling pathway	Notch receptors and ligands	(32)
Shimoda et al, 2017		Decreasing endocrine sensitivity	Unknown	(84)
Sturla et al, 2016	Glioblastoma	Increasing cell proliferation	Upregulation of Ki-67 protein	(87)
Chen et al, 2019	Endometrial carcinoma	Increasing cell proliferation and migration	Unknown	(88)
Sepe et al, 2002	Neuroblastoma	Increasing cell motility	p21/Waf1 and p16	(90)
Luu et al, 2009	Non-small cell lung cancer	Increasing invasiveness and metastatic	Unknown	(91)
Lee, 2008	Gastric carcinoma	Promoting growth and migration	Unknown	(92)