Figure 1.

RASA1 domain and potential function. The GAP domain at RASA1 C-terminus functions mainly as a catalyser for GTP. PH is connected to a Btk motif that facilitates membrane binding upon C2 interaction with the lipid. SH2 and SH3 domains at the N-terminal of RASA1 promote protein-protein interactions. RASA1, Ras p21 protein activator 1; PH, pleckstrin homology domain; Bruton's tyrosine kinase; SH2, Src homology 2; SH3, Src homology 3; GAP, GTPase-activating protein; GTP, guanosine triohosphte.