Table II.
Role of RASA1 and related factors in various pathologic processes.
| Various pathological processes | RASA1 and RASA1-associated factors | (Refs.) |
|---|---|---|
| CM-AVM | RASA1, EPHB4 | (29,30) |
| KTWS | RASA1, KRIT1 | (31,33) |
| SWS | RASA1, Nrf2 | (34,35) |
| VGAM | RASA1, ACVRL1 | (36,37) |
| MEF2C-related disorders | RASA1, MECP2, CDKL5 | (38) |
| PKWS | RASA1 | (39,40) |
| HHT | RASA1, EPHB4, ACVRL1, GDF2 | (32,35,41,42) |
| Cardiovascular and cerebrovascular diseases | RASA1, miR-132, miR-21, miR-223, GAS5/miR-335 | (43–48) |
| Chronic renal disease | RASA1, miR-132 | (49) |
| Age-related macular degeneration | RASA1 | (50) |
| Neuropathic pain | RASA1, miR-144 | (51,52) |
RASA1, Ras p21 protein activator 1; CM-AVM, capillary malformation-arteriovenous malformation; KTWS, Klippel-Trenaunay-Weber syndrome; SWS, Sturgeon-Weber syndrome; VGAM, vein of Galen aneurysmal malformation; MEF2C-related disorders, myocyte enhancer factor 2C-related disorders; PKWS, Parkes-Weber syndrome; HHT, hereditary haemorrhagic telangiectasia; EPHB4, ephrin type-B receptor 4; KRIT, Krev interaction trapped protein 1; ACVRL1, activin receptor-like kinase 1; miR, microRNA.