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. 2020 Sep 3;7(21):2001563. doi: 10.1002/advs.202001563

Table 1.

Functions of compounds targeting m6A effectors in homeostasis

Regulator Target protein Effect Primary functions Refs.
Rhein et al. FTO Inhibit Reversibly bind FTO enzyme and competitively prevent the recognition of m6A substrates [158]
MO‐I‐500 FTO Inhibit Inhibit survival and/or colony formation of SUM149‐MA cells [158, 160]
Meclofenamic acid (MA) and MA2, the ethyl ester form of MA FTO Inhibit Inhibit glioblastoma stem cells tumorigenesis [161, 162]
R‐2‐hydroxyglutarate (R‐2HG) FTO Inhibit Antileukemic activity [140]
Epigallocatechin gallate FTO Inhibit Reduce the expression of FTO and adipogenesis [154]
IOX3 ALKBH5 Inhibit Inhibitor of ALKHB5 [163]
Citrate ALKBH5 Inhibit Modest inhibitor of ALKHB5 [164]