Table 1.
Regulator | Target protein | Effect | Primary functions | Refs. |
---|---|---|---|---|
Rhein et al. | FTO | Inhibit | Reversibly bind FTO enzyme and competitively prevent the recognition of m6A substrates | [158] |
MO‐I‐500 | FTO | Inhibit | Inhibit survival and/or colony formation of SUM149‐MA cells | [158, 160] |
Meclofenamic acid (MA) and MA2, the ethyl ester form of MA | FTO | Inhibit | Inhibit glioblastoma stem cells tumorigenesis | [161, 162] |
R‐2‐hydroxyglutarate (R‐2HG) | FTO | Inhibit | Antileukemic activity | [140] |
Epigallocatechin gallate | FTO | Inhibit | Reduce the expression of FTO and adipogenesis | [154] |
IOX3 | ALKBH5 | Inhibit | Inhibitor of ALKHB5 | [163] |
Citrate | ALKBH5 | Inhibit | Modest inhibitor of ALKHB5 | [164] |