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. Author manuscript; available in PMC: 2021 Jun 14.
Published in final edited form as: Nat Genet. 2020 Dec 14;53(1):100–109. doi: 10.1038/s41588-020-00744-4

Fig. 6. Model for the consequences of WAPL and RAD21 depletion.

Fig. 6

WAPL depletion results in an accumulation of cohesin at CTCF-binding sites. RAD21 depletion leads to a general loss of cohesin from the genome. Both WAPL and RAD21 depletion results in loss of cohesin binding turnover from cell-type-specific transcription factor binding sites and decreased 3D genome interactions between promoters and these sites.