Table 3. Functionalization of natural product and drug derivatives.^a .

^aConditions: All reactions were carried out with NiCl₂ (15 mol%), ligand L12 (20 mol%), 1 (0.15 mmol), 2 (0.10 mmol), DEMS (0.25 mmol), KF (0.25 mmol) and DCE:DMF (0.5 mL) at room temperature for 40 hours. The enantiomeric excesses (e.e.s) and diastereomeric ratios (d.r.s) were determined using HPLC analysis (see Supplementary Information section 6 for full details).