Table 2. Relatedness of E. faecium associated with carriage and invasive disease.
| Patient ID |
Clinical samples | Stool samples | Relatedness analysis | |||||
|---|---|---|---|---|---|---|---|---|
| Sample type |
No. of samples1 (colonies sequenced) |
Isolate subtype (Sequence type) (SNP range) |
No. of stool samples1 (colonies sequenced) |
Stool subtype(s) (Sequence type)2 |
SNP distance: matching infection/stool subtype |
Classification of stool subtype |
Epidemiological link3 (SNP distance with isolate from linked case) |
|
| C016 | Blood | 8 (56) | 12B (80)(0-3) | 6 (38) | 12B (80), 32A (262), 15A (80), 25A (80), 47A (78) | 0 to 5 | Index | None |
| C027 | Blood | 1 (1) | - | 0 | - | - | - | - |
| D041 | Blood | 1 (10) | 47A (78) (0-0) | 3 (15) | 47A (78), 49A (1454), 5A (280) | 0 to 4 | Acquired | Strong link with patient D034 (0) |
| C076 | Surgical Biopsy |
1 (1) | 15A (80) | 2 (6) | 15A (80), 37B (17) | 0 to 2 | Index | Weak link with D012 (6) |
| D049 | Blood | 1 (10) | 15A (80) (0-1) | 2 (12) | 15A (80), 28B (80), 5A (280), 37B (17) | 1 to 2 | Acquired | Weak link with C084 (1) |
| C095 | Blood | 2 (20) | 45A (80) (0-3) | 1 (5) | 45A (80) | 1 to 4 | Acquired | Strong link with C092 (0) |
1
Samples positive for E. faecium.
2
Subtypes identified across all stool samples from the same patient.
3
Strong link, defined as admission to the same bay, room or ward at the same time or within 7 days following discharge of the previous occupant; admission to the same ward separate by more than 7 days or admission to the study hospital but to different wards were considered weak epidemiological link.