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. Author manuscript; available in PMC: 2021 Apr 19.
Published in final edited form as: Nat Cell Biol. 2020 Oct 19;22(11):1382–1395. doi: 10.1038/s41556-020-00592-8

Extended Data Fig. 9. PLCγ1 deletion accelerates lung tumorigenesis in mice.

Extended Data Fig. 9

(a) Representative hematoxylin & eosin (H&E) staining of LSL-KrasG12D/WT;p53flox/flox;Plcγ1wt/wt, LSL-KrasG12D/WT;p53flox/flox;Plcγ1wt/flox and LSL-KrasG12D/WT;p53flox/flox;Plcγ1flox/flox mouse lung sections, 10 weeks after Cre induction. Scale bar: 5000μm.

(b) Representative immunohistochemistry images showing Ki67-positive cell staining in mouse lung tumors from LSL-KrasG12D/WT;p53flox/flox;Plcγ1wt/wt, KrasG12D/WT;p53flox/flox;Plcγ1wt/flox and LSL-KrasG12D/WT;p53flox/flox;Plcγ1flox/flox mice 10 weeks after Cre induction. This is related to main Fig. 7e.