Fig. 3.

Doublet/dinucleotide Base Substitution and Indel Signatures. A, Number of dinucleotide substitutions across the collection of lung, liver, kidney and forestomach tumours. Liver tumours have, in general, a higher number of dinucleotide substitutions than lung tumours (two-sided Mann-Whitney U-test). Cobalt induced lung tumours have a significant higher number of altered dinucleotides compared to the other lung tumours (FDR-corrected one-sided Mann-Whitney U-test). The central line represents the median, the lower line is the first quantile (Q₁) and the upper line is the third quantile (Q₃). The upper whisker extends from Q₃ to 1.5 times the inter-quartile range (IQR), the lower whisker extends from Q ₁to 1.5 times the IQR. B, Median number and types of doublet base substitutions per tumour tissue and chemical exposure. C, Number of indels in lung, liver, kidney and forestomach tumours. Lung tumours have, in general, a higher number of indels than liver tumours (two-sided Mann-Whitney U-test). Boxes and line are as described in A. D, Relative contribution of COSMIC indel Signatures. The types of indels are mainly driven by tissue type, with lung tumours having an higher mID2 activity (two-sided Mann-Whitney U-test). Signature 0 (red) represents background. More details are provided in Extended Data Fig. 5.