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. Author manuscript; available in PMC: 2021 Mar 29.
Published in final edited form as: Nat Genet. 2020 Sep 14;52(10):1057–1066. doi: 10.1038/s41588-020-0687-1

Extended Data Fig. 8. Immune properties of tumours at different basal death rates.

Extended Data Fig. 8

(a) The number of detectable neoantigen-associated mutations (at simulated sequencing depth of ~50x) in n=50 simulated tumours with increasing base (non-immunogenic) death rate. The bottom panel shows the ratio of tumours with different levels of immune escape. Violin widths represent raw data density. (b) Cumulative VAF distribution as a function of the inverse of the frequency, for all mutations (grey) and antigenic mutations (red) at increasing base death rate, db. The thick line shows the mean of n=100 simulated cumulative distributions, the shaded regions represent ±1 standard deviation around this mean. At very high base death (last panel), the VAF distribution of neoantigens and neutral mutations overlaps as tumours are exclusively immune-escaped and evolve neutrally.