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. Author manuscript; available in PMC: 2021 Mar 29.
Published in final edited form as: Nat Genet. 2020 Sep 14;52(10):1057–1066. doi: 10.1038/s41588-020-0687-1

Extended Data Fig. 4. VAF distribution of neoantigens under different selection strengths and mutation-antigenicity thresholds.

Extended Data Fig. 4

Cumulative VAF distribution as a function of the inverse of the frequency, for all mutations (grey) and antigenic mutations (red) at increasing selection strengths (top to bottom) and mutation-antigenicity threshold (Tm) applied to label mutations as antigenic (left to right). The thick line shows the mean of 100 simulated cumulative distributions, the shaded regions represent ±1 standard deviation around this mean.