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. Author manuscript; available in PMC: 2021 Mar 29.
Published in final edited form as: Nat Immunol. 2020 Aug 3;21(10):1244–1255. doi: 10.1038/s41590-020-0744-z

Figure 2. Abatacept decreases Tfh during an ongoing autoimmune response in mice.

Figure 2

Abatacept or Control-Ig were injected every two to three days i.p. into 6-8 week old DO11.10 x RIP-mOVA mice. At day 11, pancreas-draining lymph nodes (panLN) and spleens were harvested for analysis. (a) Representation of treatment scheme. (b,c) Collated data for frequencies (b) and absolute numbers (c) of Tfh cells in gated CD4+ cells. Data are compiled from two independent experiments; n=10 mice in each treatment group. Mean + SD are shown. Two-tailed Mann-Whitney U test; ***, p < 0.001; **, p < 0.01.