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. Author manuscript; available in PMC: 2021 Mar 29.
Published in final edited form as: J Mol Biol. 2021 Feb 19;433(8):166878. doi: 10.1016/j.jmb.2021.166878

Figure 7:

Figure 7:

a) Inhibition of α-syn seeding activity by Brazilin in RT-QuIC using 2 μL of BH from three PD patient isolated post-mortem from the pre-frontal cortex and 6 μM K23Q mutant α-syn as substrate in ThT Buffer. Graphs represent average ± SD of quadruplicate curves and each reaction was performed using brain dilution of 10−4. CBD represents BH from post mortem confirmed corticobasal degeneration cases b) Transmission electron microscopy images of RT-QuIC end products from various PD patient brains. Scale bar is 200 nm.