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. Author manuscript; available in PMC: 2021 Mar 30.
Published in final edited form as: Nat Microbiol. 2020 May 11;5(8):1016–1025. doi: 10.1038/s41564-020-0716-y

Extended Data Fig. 9. Schematic demonstrating the proposed mechanism of substrate capture and translocation by RagAB.

Extended Data Fig. 9

Peptide ligands to be imported by the RagAB system are predominantly generated by the action of gingipains on serum and tissue-derived proteins. 1. A lid-open state of RagAB permits peptide binding. 2. Contributions from both RagA and RagB to peptide binding elicits closure of the lid, forming the transport-competent state of the complex. This is signalled across the OM by perturbation of the TonB box region on the periplasmic side of the plug domain, making it accessible to TonB. 3. According to the literature consensus, TonB-mediated disruption of the plug permits substrate translocation and a return to the open state of RagAB.