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. Author manuscript; available in PMC: 2021 Jun 22.
Published in final edited form as: Nat Chem. 2020 Dec 22;13(1):47–55. doi: 10.1038/s41557-020-00601-1

Extended Data Fig. 2. Synthesis of hybrid polyether HL324 (32).

Extended Data Fig. 2

Preparation of analog HL324 (32) was performed through anti-selective (Evans-Saksena) reduction of the ketone-functionality of 26 followed by DCC-mediated coupling with 5-chloromethylidene tetronate. rt = room temperature, TBAF = tetrabutylammonium fluoride, DMF = N,N-dimethylformamide, DCC = N,N’-dicyclohexylcarbodiimide, DMAP = 4-dimethylaminopyridine, HPLC = high pressure liquid chromatography.