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. Author manuscript; available in PMC: 2021 Apr 6.
Published in final edited form as: Chem Rev. 2014 Apr 10;114(11):5815–47. doi: 10.1021/cr400401e

Figure 8. Structures and electrostatic surfaces of ω-conotoxins.

Figure 8

Important residues identified through SAR studies are indicated on the left panels. ω-MVIIA, ω-MVIIC and ω-GVIA target mammalian voltage-gated calcium channels, whereas ω-TxVIIA is a mollusc-selective toxin. Obvious differences in electrostatic potentials likely account for the different pharmacologies.