Table 1. Conopeptide gene superfamilies.

Gene superfamily	# Protein precursorsb	# Nucleic sequencesb	Cysteine frameworks occurring in superfamily	Consensus of signal peptide sequencec
A	202	234	I, II, IV, XIV	MGMRMMFTVFLLVVLATTVVSXTS
B1	14	5	(disulfide poor conantokins)	MXLYTYLYLLVPLVTFHLILGXGT
B2	1		VIII	MLRLITAAVLVSACLA
B3	1	1	XXIV	METLTLLWRASSSCLLVVLSHSLLRLLG
C	4	7	(disulfide poor contulakins)	MXXAYWVMVMMMVXIXAPLSEG
D	28	14	XV, XX	MPKLEMMLLVLLILPLXYFDAAGG
E	1		XXII	MMTRVFFAMFFLMALTEG
F	1			MQRGAVLLGVVALLVLWPQAGA
G	1	1	XIII	MSGMGVLLLVLLLVMPLAA
H	7		VI/VII	MNTAGRLLLLCLALGVLVFESLG
I1	17	10	VI/VII, XI	MKLXXTFLLXLXILPXXXG
I2	57	38	XI, XII	MMFRXTSVXCFLLVIXXLNL
I3	7	8	VI/VII, XI	MKLVLAIVXILMLLSLSTGA
J	12	12	XIV	MPSVRSVTCCCLLWXMLSXXLVTPGSP
K	4	1	XXIII	MIMRMTLTLFVLVVMTAASASG
L	13	8	XIV	MXXXVMFXVXLXLTMPLTX
M	361	333	I, II, III, IV, VI/VII, IX, X, XIV, XVI	MMXKXGVXMLXIXLXLFPLXXXQLDA
N	3		XV	MSTLKMMLLILLLLLPXATFDSDG
O1	460	559	I, VI/VII, XII, XIV	MMKLTCVXIVAVLFLTAXXLXTAXXSA
O2	84	73	VI/VII, XIV, XV	MEKLTILLLVAAVLMSTQALXQS
O3	28	22	VI/VII	MSGLGIMVLTLLLLVFMXTSHQ
P	9	5	IX	MHXXLXXSAVLXLXLLXAXXNFXXVQ
S	13	8	VIII	MMXKMGAMFVLLLLFXLXSSQQ
T	157	143	I, V, X, XVI	MRCLPVFXILLLLIXSAPSVDA
V	2	2	XV	MMPVILLLLLSLAIRXXDG
Y	1	1	XVII	MQKATVLLLALLLLLPLSTA

^aConopeptides gene superfamilies are defined by the similarity of the signal peptide regions in conopeptide precursors. The founding reference for each superfamily can be found on the ConoServer website (http://www.conoserver.org), which also provides regular updates to this table and additional statistics. Definitions of the cysteine frameworks are in Table 2.

^bNumber of protein and nucleic precursors catalogued in ConoServer.

^cThe consensus signal sequence was obtained by establishing determining amino acids with at least 60% of conservation at each position of the signal sequence in all protein precursors in ConoServer.