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. Author manuscript; available in PMC: 2021 Apr 7.
Published in final edited form as: Anal Chem. 2016 Oct 27;88(22):10876–10883. doi: 10.1021/acs.analchem.6b01410

Figure 4.

Figure 4

Current vs time curves for growing cancer spheroids (A-C) and a pancreatic microislet, which was not expected to grow (D). (A) Continuous recordings during 90 h show a noticeable discontinuity upon medium exchange after 42 h in the peak-to-baseline (ΔI) current at 81 kHz. (B) The same data have been normalized with the corresponding baseline currents so that a growth curve without discontinuity upon medium exchange results. (C) Normalized ΔI norm currents of six exemplary cancer spheroids after applying a movingaverage method including 10 subsequent measurement values. (D) ΔI norm for a pancreatic microislet, which expectedly does not grow. In contrast to the cancer spheroids, there are no large variations or a current decrease. The significantly smaller values in panel D compared to panel C are a consequence of the smaller size of the microislet (150 μm diameter).