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. Author manuscript; available in PMC: 2021 Apr 8.
Published in final edited form as: Trends Endocrinol Metab. 2016 May 21;27(7):516–528. doi: 10.1016/j.tem.2016.04.011

Figure 2. Reported Genetic Associations and Genetic Correlations between Phenotypes.

Figure 2

(A) Genome-wide significant loci associated with menarche, menopause, polycystic ovary syndrome, FSH and LH levels, and menstrual cycle length; and genes associated with monogenic forms of POI. (B) Genetic correlations between phenotypes reflecting ovarian physiology and overall health status. Data are from published studies [9,10,19] that report genetic correlations based on observed pleiotropy between loci or LD score regression analysis. Abbreviations: AMH, anti-Müllerian hormone; FSH, follicle-stimulating hormone; LD, linkage disequilibrium; LH, luteinizing hormone; PAI-1, plasminogen activator inhibitor type 1; PCOS, polycystic ovary syndrome; POI, premature ovarian insufficiency.