Table 2. Baseline haemodynamics and the change at week 2 and week 12.
| Variable | Baseline (Visit 2) Mean ±SD | Week 2 (Visit 3) Change(95% CI) | Week 12/HYP (Visit 8/HYP) Change(95% CI) |
|---|---|---|---|
| Systolic BP (mmHg) | 117±13 | +12 (6,18); P<0.001 | +12 (4,19); P<0.001 |
| Diastolic BP (mmHg) | 73±9 | +8 (5,12); P<0.001 | +10 (5,15); P<0.001 |
| MAP (mmHg) | 85±10 | +9 (4,13); P<0.001 | +10 (5,16); P<0.001 |
| Heart Rate (bpm) | 89±14 | -11(-16,-7); P<0.001 | -9(-15,-3); P<0.001 |
| Cardiac output (L/min) | 4.88±1.42 | -0.95 (-1.25, -0.65); P<0.001 | -1.35 (-1.73, -0.98); P<0.001 |
| Cardiac Index (L/min/m3) | 2.70±0.72 | -0.51 (-0.76, -0.27); P<0.001 | -0.86 (-1.18, -0.53); P<0.001 |
| PVR (dynes*s/cm5) * | 1552±576 | +504 (288, 728); P<0.001 | +888 (616, 1168); P<0.001 |
| AIx (%) † | 16±10 | +7 (4,11); P<0.001 | +6 (1,11); P<0.001 |
| Aortic PWV (m/s) ‡ | 8.0±2.1 | +0.4 (-0.3,1.2); P=0.23 | +1.3 (0.3,2.2); P<0.01 |
| 24h Ambulatory SBP (mmHg) | 118±12 | +6 (-16, 25); P=0.02 | +6 (-12, 24); P=0.08 |
| 24h Ambulatory DBP (mmHg) | 75±8 | +6 (-6, 18); P<0.001 | +5 (-5, 19); P=0.01 |
*
derived from PVR= (MAP/CO)*80
†
adjusted for HR
‡
adjusted for MAP and HR. The significance was determined using a simple ANCOVA model, with fixed effects for Visit, adjusting for baseline value. AIx denotes augmentation index; BP, blood pressure; DBP, diastolic blood pressure; MAP, mean arterial pressure; PVR, peripheral vascular resistance; PWV, pulse wave velocity and SBP, systolic blood pressure.