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. Author manuscript; available in PMC: 2021 Apr 12.
Published in final edited form as: J Appl Anim Ethics Res. 2020 May 26;2(2):151–176. doi: 10.1163/25889567-BJA10002

Table 1. Milestones in genetic alteration of NHPS.

Milestone Species Country Reference
First transgenic NHP (ANDi); GFP reporter gene M. mulatta USA Chan et al. (2001)
First transgenic NHP disease model— Huntington’s disease (HD); human mutant huntingtin gene M. mulatta USA Yang et al. (2008)
Germline transmission (inherited vector-integrated transgene from parents); enhanced GFP gene C. jacchus Japan Sasaki et al. (2009)
First GE NHP using TALENS—Rett syndrome (RTT); human MeCP2 gene M. mulatta M. fascicularis China Liu et al. (2014)
First GE NHP using CRISPR/Cas9; Ppar-γ and Rag1 genes M. fascicularis China Niu et al. (2014)
Generation of chimeric fetuses using embryonic stem cells M. fascicularis China Chen et al. (2015)
First GE NHP using ZFNS/TALENS— model of severe combined immunodeficiency (SCID); IL2RG gene C. jacchus Japan Sato et al. (2016)
Cloning of a gene-edited NHP using SCNT; knockout of circadian transcription factor BMAL1 M. fascicularis China Liu et al. (2019)