First transgenic NHP (ANDi); GFP reporter gene |
M. mulatta
|
USA |
Chan et al. (2001)
|
First transgenic NHP disease model— Huntington’s disease (HD); human mutant huntingtin gene |
M. mulatta
|
USA |
Yang et al. (2008)
|
Germline transmission (inherited vector-integrated transgene from parents); enhanced GFP gene |
C. jacchus
|
Japan |
Sasaki et al. (2009)
|
First GE NHP using TALENS—Rett syndrome (RTT); human MeCP2 gene |
M. mulatta
M. fascicularis
|
China |
Liu et al. (2014)
|
First GE NHP using CRISPR/Cas9; Ppar-γ and Rag1 genes |
M. fascicularis
|
China |
Niu et al. (2014)
|
Generation of chimeric fetuses using embryonic stem cells |
M. fascicularis
|
China |
Chen et al. (2015) |
First GE NHP using ZFNS/TALENS— model of severe combined immunodeficiency (SCID); IL2RG gene |
C. jacchus
|
Japan |
Sato et al. (2016)
|
Cloning of a gene-edited NHP using SCNT; knockout of circadian transcription factor BMAL1
|
M. fascicularis
|
China |
Liu et al. (2019)
|