Table 1. Drugs already approved by FDA for hematological disease treatment.

Name	Composition		Disease	Year of approval	References
	NPs	Active substances
CosmoFer/INFeD/Ferrisat	Iron dextrane colloid		Iron deficient anemia	1992, FDA	[160]
Doxil/Caelyx	Liposomes	Doxorubicin	Multiple myeloma	1995, FDA	[161,162]
DexFerrum/DexIron	Iron dextrane colloid		Iron deficient anemia	1996, FDA	[163]
Depocyt	Liposomes	Cytarabine	Lymphomatous meningitis	1999, FDA	[164,165]
FerrIecit	Iron gluconate colloid		Anemia treatment in patients with chronic kidney disease	1999, FDA	[166]
Venofer	Iron sucrose colloid		Anemia treatment in patients with chronic kidney disease	2000, FDA	[167]
Oncaspar	Liposomes	Asparaginase	Acute lymphoblastic leukemia	2006, FDA	[168]
Feraheme	Iron polyglucose sorbitol carboxymethylether colloid		Anemia treatment in patients with chronic kidney disease	2009, FDA	[169]
Monofer	Iron isomaltoside colloid		Iron deficient anemia when oral method do not work or iron delivery is required immediately	2009, some of Europe	[170]
Marqibo	Liposomes	Vincristine	Acute lymphoblastic leukemia	2012, FDA	[171,172]
Diafer	Iron isomaltoside colloid		Iron deficient anemia	2012, some of Europe	[173]
Injectafer/Ferinject	Iron carboxymaltose colloid		Iron deficient anemia	2013, FDA	[174]
Vyxeos	Liposomes	Daunorubicin and cytarabine	Acute myeloid leukemia	2017, FDA	[175–177]