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. Author manuscript; available in PMC: 2021 Apr 14.
Published in final edited form as: N Engl J Med. 2019 Aug 1;381(5):420–431. doi: 10.1056/NEJMoa1900100

Table 3. Predictors of Death at 28 Days after Blood Transfusion in Children with a Hemoglobin Level of Less Than 6 g per Deciliter.

Factor at Randomization Hazard Ratio (95% CI) from Multivariable Model*
Malaria 0.52 (0.34–0.78)
Higher oxygen saturation 0.91 (0.88–0.94)
Higher respiratory rate 1.03 (1.01–1.04)
Higher lactate level 1.09 (1.04–1.15)§
HIV positivity 2.58 (1.32–5.05)
Convulsions in current illness 1.87 (1.05–3.33)
Blantyre coma score
      5 1.00
      4 0.83 (0.31–2.17)
      3 2.19 (0.97–4.95)
      2 2.48 (1.22–5.05)
      1 3.29 (0.97–12.5)
      0 3.21 (1.04–9.89)
Blood type
      O 1.00
      A 1.03 (0.64–1.68)
      B 0.74 (0.43–1.27)
      AB 2.59 (1.41–4.78)
*

Estimates were adjusted for randomized comparison, continuous variation in temperature, and the interaction between the two with the use of natural cubic splines (details in the Supplementary Appendix).

Shown is the hazard ratio for each increment of 1% in oxygen saturation.

Shown is the hazard ratio for each increment of 1 breath per minute in the Respiratory rate.

§

Shown is the hazard ratio for each increment of 1 mmol per liter in the lactate level.

The Blantyre coma scale is used to assess malarial coma in children. Scores range from 0 to 5, with lower scores indicating lower levels of consciousness.