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. Author manuscript; available in PMC: 2021 Apr 15.
Published in final edited form as: Cancer Prev Res (Phila). 2020 Feb 18;13(6):509–520. doi: 10.1158/1940-6207.CAPR-19-0521

Table 2. Genetic Risk Score (GRS) discrimination / odds ratio for colorectal cancer per standard deviation increase in risk score, stratified by self-reported white / non-white ethnicity.

Mean standardised GRS (SD), n=430,511 OR (95%CI) per 1SD of GRS
Without CRC (n=427,908) With CRC (n=2,603) Only self-reported white ethnicity (n=419,579) Only non-white ethnic backgrounds (n=21,562) All (n=430,511)
Abe 2017 -0.01 (1.00) 0.16 (0.98) 1.20 (1.15 - 1.25) 1.23 (0.98 - 1.53) 1.18 (1.14 - 1.22)
Dunlop 2013 0.00 (1.00) 0.22 (0.98) 1.25 (1.20 - 1.30) 1.22 (0.98 - 1.52) 1.25 (1.20 - 1.30)
Frampton 2016 0.00 (1.00) 0.17 (1.00) 1.18 (1.13 - 1.23) 1.40 (1.12 - 1.76) 1.18 (1.14 - 1.23)
Hosono 2016 0.00 (1.00) 0.13 (0.97) 1.16 (1.12 - 1.21) 1.10 (0.88 - 1.36) 1.14 (1.10 - 1.19)
Hsu 2015 -0.01 (1.00) 0.26 (0.98) 1.30 (1.25 - 1.35) 1.27 (1.01 - 1.61) 1.30 (1.25 - 1.35)
Huyghe 2019 -0.01 (1.00) 0.47 (0.99) 1.60 (1.50 - 1.72) 1.10 (0.73 - 1.65) 1.60 (1.50 - 1.72)
Ibanez-Sanz 2017 0.00 (1.00) 0.19 (1.00) 1.20 (1.16 - 1.25) 1.28 (1.02 - 1.60) 1.22 (1.17 - 1.26)
Iwasaki 2017 0.00 (1.00) 0.13 (1.00) 1.15 (1.11 - 1.20) 0.96 (0.75 - 1.21) 1.14 (1.10 - 1.19)
Jenkins 2016 -0.01 (1.00) 0.23 (0.97) 1.28 (1.23 - 1.33) 1.10 (0.88 - 1.38) 1.26 (1.21 - 1.31)
Jeon 2018 0.00 (1.00) 0.29 (0.99) 1.33 (1.28 - 1.38) 1.42 (1.13 - 1.79) 1.33 (1.28 - 1.39)
Smith 2018 -0.01 (1.00) 0.23 (0.98) 1.27 (1.22 - 1.32) 1.39 (1.11 - 1.73) 1.26 (1.22 - 1.31)
Wang 2013 0.00 (1.00) 0.02 (0.98) 1.01 (0.97 - 1.05) 1.08 (0.85 - 1.36) 1.02 (0.98 - 1.06)
Xin 2018 0.00 (1.00) 0.13 (1.00) 1.15 (1.11 - 1.20) 1.24 (1.04 - 1.49) 1.14 (1.09 - 1.18)
Yarnall 2013 0.00 (1.00) 0.19 (1.01) 1.21 (1.17 - 1.26) 1.22 (0.98 - 1.53) 1.22 (1.17 - 1.26)