Table 2. Genetic Risk Score (GRS) discrimination / odds ratio for colorectal cancer per standard deviation increase in risk score, stratified by self-reported white / non-white ethnicity.

	Mean standardised GRS (SD), n=430,511			OR (95%CI) per 1SD of GRS
	Without CRC (n=427,908)	With CRC (n=2,603)	Only self-reported white ethnicity (n=419,579)	Only non-white ethnic backgrounds (n=21,562)	All (n=430,511)
Abe 2017	-0.01 (1.00)	0.16 (0.98)	1.20 (1.15 - 1.25)	1.23 (0.98 - 1.53)	1.18 (1.14 - 1.22)
Dunlop 2013	0.00 (1.00)	0.22 (0.98)	1.25 (1.20 - 1.30)	1.22 (0.98 - 1.52)	1.25 (1.20 - 1.30)
Frampton 2016	0.00 (1.00)	0.17 (1.00)	1.18 (1.13 - 1.23)	1.40 (1.12 - 1.76)	1.18 (1.14 - 1.23)
Hosono 2016	0.00 (1.00)	0.13 (0.97)	1.16 (1.12 - 1.21)	1.10 (0.88 - 1.36)	1.14 (1.10 - 1.19)
Hsu 2015	-0.01 (1.00)	0.26 (0.98)	1.30 (1.25 - 1.35)	1.27 (1.01 - 1.61)	1.30 (1.25 - 1.35)
Huyghe 2019	-0.01 (1.00)	0.47 (0.99)	1.60 (1.50 - 1.72)	1.10 (0.73 - 1.65)	1.60 (1.50 - 1.72)
Ibanez-Sanz 2017	0.00 (1.00)	0.19 (1.00)	1.20 (1.16 - 1.25)	1.28 (1.02 - 1.60)	1.22 (1.17 - 1.26)
Iwasaki 2017	0.00 (1.00)	0.13 (1.00)	1.15 (1.11 - 1.20)	0.96 (0.75 - 1.21)	1.14 (1.10 - 1.19)
Jenkins 2016	-0.01 (1.00)	0.23 (0.97)	1.28 (1.23 - 1.33)	1.10 (0.88 - 1.38)	1.26 (1.21 - 1.31)
Jeon 2018	0.00 (1.00)	0.29 (0.99)	1.33 (1.28 - 1.38)	1.42 (1.13 - 1.79)	1.33 (1.28 - 1.39)
Smith 2018	-0.01 (1.00)	0.23 (0.98)	1.27 (1.22 - 1.32)	1.39 (1.11 - 1.73)	1.26 (1.22 - 1.31)
Wang 2013	0.00 (1.00)	0.02 (0.98)	1.01 (0.97 - 1.05)	1.08 (0.85 - 1.36)	1.02 (0.98 - 1.06)
Xin 2018	0.00 (1.00)	0.13 (1.00)	1.15 (1.11 - 1.20)	1.24 (1.04 - 1.49)	1.14 (1.09 - 1.18)
Yarnall 2013	0.00 (1.00)	0.19 (1.01)	1.21 (1.17 - 1.26)	1.22 (0.98 - 1.53)	1.22 (1.17 - 1.26)