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. Author manuscript; available in PMC: 2021 Apr 19.
Published in final edited form as: Nat Genet. 2020 Oct 19;52(11):1247–1255. doi: 10.1038/s41588-020-00712-y

Extended Data Fig. 7. CHESS performance on differently sized simulated matrices with realistic noise and sequencing depth.

Extended Data Fig. 7

Shown are empirically determined CHESS p- and z-scores (details in Online Methods) for comparisons of R with a read depth of 100 read pairs / 100 bins and a resized copy Q. Scaling factor is indicated on the x-axis. A noise level of 25 % was added to both matrices independently. Sequencing depth was adjusted to 100 k/Mb. Solid lines indicate the mean, shaded areas the standard deviation over 100 simulations per parameter combination. Colours correspond to the different sizes of R.