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. Author manuscript; available in PMC: 2021 Apr 19.
Published in final edited form as: Nat Genet. 2020 Oct 19;52(11):1247–1255. doi: 10.1038/s41588-020-00712-y

Figure 2. CHESS evaluation on synthetic Hi-C matrices.

Figure 2

a-c, Tests for the tolerance of CHESS to increasing levels of simulated experimental noise. a, Schematic representation of the tests for the sensitivity of CHESS to noise. b, Empirically determined CHESS P values on synthetic matrices with increasing levels of noise (details in Online Methods). c, CHESS z-scores on synthetic matrices with increasing levels of noise. d-e, Tests for the performance of CHESS when comparing matrices of different sizes. d, Schematic representation of different scaling factors used to generate a query matrix Q from a reference R. e, Dependence of CHESS P values on the scaling factor of synthetic matrices Q and R. f, Dependence of CHESS z-scores on the scaling factor. b, c and e, f, Solid lines indicate the mean, shaded areas the standard deviation over 100 simulations per parameter combination. Lowest possible P value in all tests: 0.001.