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. Author manuscript; available in PMC: 2021 Apr 19.
Published in final edited form as: Nat Genet. 2020 Oct 19;52(11):1247–1255. doi: 10.1038/s41588-020-00712-y

Extended Data Fig. 3. Additional analysis of the CHESS algorithm.

Extended Data Fig. 3

a, Uniform distribution of empirically determined CHESS p-values for comparisons of matrices with 100 % noise added. b, Distribution of structural similarity scores (ssim) for background and truth comparisons at 25 k/Mb and 1.5 M/Mb simulated sequencing depth. Above each: Fractional change (value at x % noise/value at 0 % noise) of the standard deviation (std) of background scores and mean of truth scores over 100 simulations per parameter combination.