Skip to main content
. Author manuscript; available in PMC: 2021 Apr 20.
Published in final edited form as: Crit Rev Biochem Mol Biol. 2021 Feb 17;56(2):157–177. doi: 10.1080/10409238.2021.1881433

Figure 4.

Figure 4

Mechanisms of post-replicative mismatch repair. Single nucleotide mismatches or 1–2 nucleotide insertions/deletions (IDLs) and larger heteroduplex loops are recognized by MutSα and MutSβ, respectively. Mismatch recognition induces ATP binding by MutSα/β which recruits and activates MLH1-PMS2 (MutLα) endonuclease to make single strand nicks. This activity is directed toward the nascent strand containing a preexisting nick through an interaction with PCNA. The mismatch can then be excised by EXO1 and the nascent strand may be re-synthesized by DNA polymerase δ.